药物科学与工程系

重大疾病（动脉粥样硬化、糖尿病、肿瘤等）药理学研究

1.国家自然科学基金青年科学基金项目：抑制血管钙化—DNA拓扑异构酶II抑制剂抗动脉粥样硬化新机制，项目编号：81803517，2019.1-2021.12，结题，主持

2.威廉希尔亚洲公司学术新人提升计划B项目，水凝胶包裹的LXR激动剂增强其抗肿瘤功能、抑制脂肪肝发生, DNA拓扑异构酶II在动脉血管钙化中的相关作用机制研究，项目编号：JZ2020HGTB0058，2020.4-2021.12，结题，主持

3.威廉希尔亚洲公司人才引进科研启动经费

4.威廉希尔亚洲公司学术新人提升计划A项目，DNA拓扑异构酶II在动脉血管钙化中的相关作用机制研究，项目编号：JZ2018HGTA0226，2018.5-2019.12，结题，主持

5.横向项目：龙生蛭胶囊对高血脂症的作用和机制研究，项目编号：W2018JSKF0154，2018.5-2019.5，结题，主持

6.横向课题：辅酶I及组合药物神经细胞活性筛选，项目编号：W2019JSFW0595，2019.11-2020.07，结题，主持

7.横向项目：用血管痉挛性偏头痛模型探索愈风宁心滴丸解痉止痛的作用和机制研究，项目编号：W2020JSFW0418，2020.09-2020.12，结题，主持

8.横向项目：脂肪肝检测试剂盒开发，项目编号：W2022JSKF0204，2022.01-2022.12，结题，主持

9.南开大学药物化学生物学国家重点实验室开放课题：DNA拓扑异构酶II在动脉血管钙化中的相关作用机制研究，项目编号：2018006，2018.1-2018.12，结题，主持

1.Liu Z#, Zhang Z#, Zou T, Fang M, Wang T, Meng H, Chen Y, Duan Y, Wei L, Han J, Li Q*, Yang X*. Discovery of novel dihydropyrazole-stilbene derivatives for ameliorating heart failure through modulation of p38/NF-kB signaling pathway. Bioorg Chem. 2022 Dec;129:106206. doi: 10.1016/j.bioorg.2022.106206.

2.Guilan Chen#, Yingquan Liang#, Dandan Wang, Feng Zhang, Rong Huang, Yu Ge, Chenzhong Liao, Xuegong Hao, Yuanli Chen, Jihong Han, Xiaoxiao Yang*, Yajun Duan*. Polysaccharide extracted from Morchella esculenta inhibits carrageenan-induced thrombosis in mice. Journal of Functional Foods 97 (2022) 105235.

3.Daigang Yang#, Yongyao Gao#, Zequn Yin, Xuerui Wang, Xianshe Meng, Tingfeng Zou, Yajun Duan, Yuanli Chen, Chengzhong Liao, Zhouling Xie, Xiaodong Fan, Lu Sun, Jihong Han*, Xiaoxiao Yang*. Roxadustat alleviates nitroglycerin-induced migraine in mice through regulating HIF-1a/NF-kB/inflammation pathway. Acta Pharmacologica Sinica. 2023 Feb;44(2):308-320.

4.Xianshe Meng#, Shihong Zheng#, Zequn Yin, Xuerui Wang, Daigang Yang, Tingfeng Zou, Huaxin Li, Yuanli Chen, Chengzhong Liao, Zhouling Xie, Xiaodong Fan, Jihong Han, Yajun Duan* Xiaoxiao Yang*. Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-kB. Food Science and Human Wellness. 2022 accepted.

5.Dan Zhao#, Chao Xue#, Yanfang Yang, Jiaqi Li, Xiaolin Wang, Yi Chen,Shuang Zhang, Yuanli Chen, Yajun Duan, Xiaoxiao Yang*, Jihong Han*. Lack of Nogo-B expression ameliorates PPARγ deficiency-aggravated liver fibrosis by regulating TLR4-NF-κB-TNF-α axis and macrophage polarization. Biomedicine & Pharmacotherapy. 2022,153: 113444.

6.Gao Y#, Jiang X, Yang D#, Guo W, Wang D, Gong K, Peng Y, Jiang H, Shi C, Duan Y, Chen Y, Han J, Yang X*. Roxadustat, a hypoxia-inducible factor 1α activator, attenuates both long- and short-term alcohol-induced alcoholic liver disease. Front. Pharmacol. 2022,13:895710.

7.Wang X, Yang Y, Chen Y, Duan Y, Han J, Yang X*. MEK1/2 inhibitors induce class I alcohol dehydrogenase (ADH1) expression by regulating farnesoid X receptor in hepatic cell lines and C57BL/6J mouse. Mol Biol Rep. 2022 Mar 25. doi: 10.1007/s11033-022-07361-w.

8.Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y*, Yang X*. Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms. Journal of Biological Chemistry. 2022 Jan 5;298(2):101561.

9.Zhang Z#, Cao P#, Fang M, Zou T, Han J, Duan Y, Xu H, Yang X*, Li QS*. Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis. European Journal of Medicinal Chemistry. 2021 Aug 8;225:113743.

10.Fang M#, Zou T#, Yang X*, Zhang Z, Cao P, Han J, Duan Y, Ruan B*, Li QS*. Discovery of Novel Pterostilbene Derivatives That Might Treat Sepsis by Attenuating Oxidative Stress and Inflammation through Modulation of MAPKs/NF-kB Signaling Pathway. Antioxidants. 2021 Aug 24;10(9):1333.

11.Zheng S#, Cao P#, Yin Z, Wang X, Chen Y, Yu M, Xu B, Liao C, Duan Y, Zhang S, Han J, Yang X*. Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis. Food & Function 2021 Mar 15;12(5):2323-2334.

12.Yin Z#, Wang X#, Zheng S, Cao P, Chen Y, Yu M, Liao C, Zhang Z, Han J, Duan Y, Yang X*, Zhang S*. LongShengZhi Capsule attenuates Alzheimer-like pathology in APP/PS1 double transgenic mice by reducing neuronal oxidative stress and inflammation. Frontiers in Aging Neuroscience 2020 Nov 23;12:582455.

13.Wang X#, Yin Z#, Cao P, Zheng S, Chen Y, Yu M, Liao C, Zhang Z, Duan Y, Han J, Zhang S*, Yang X*. NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines. Biomedicine & Pharmacotherapy 2020 Nov 13;133:110964.

14.Wang D#, Yang X#, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J*, Duan Y*. Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression. Journal of Biological Chemistry 2020 Nov 20; 295(47):15870-15882.

15.Zhao D, Li J, Xue C, Feng K, Liu L, Zeng P, Wang X, Chen Y, Li L, Zhang Z, Duan Y, Han J*, Yang X*. TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells. Journal of Biological Chemistry 2020 Nov 27; 295(48):16314-16327.

16.Zhao D#, Xue C#, Li J, Feng K, Zeng P, Chen Y, Duan Y, Zhang S, Li X, Han J, Yang X*. Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. Biochemical and Biophysical Research Communications 2020 Dec 10;533(3):304-312.

17.Xu S, Wang Y, Yu M, Wang D, Liang Y, Chen Y, Liao C, Xie Z, Zhao B, Han J, Duan Y, Yang X. LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress. Biomedicine & Pharmacotherapy 2020 Mar;123:109803.

18.Lv X#, Yang X#, Zhan M, Cao P, Zheng S, Peng R, Han J, Xie Z, Tu Z, Liao C. Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold. European Journal of Medicinal Chemistry 2019. 111769.

19.Wei Z, Zhao D, Zhang Y, Chen Y, Zhang S, Li Q, Zeng P, Li X, Zhang W, Duan Y, Han J*, Yang X*. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-kB-TNF-a signaling pathway in a PPAR-dependent manner. Biochemical and Biophysical Research Communications 2019 Nov 19;519(4):854-860.

20.Yang S, Chen Y, Duan Y, Ma C, Liu L, Li Q, Yang J, Li X, Zhao B, Wang Y, Qian K, Liu M, Zhu Y, Yang X*, Han J*. Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice. Biomedicine & Pharmacotherapy 2019 Oct;118:109389.

21.Li Q#, Chen Y#, Zhao D, Yang S, Zhang S, Wei Z, Wang Y, Qian K, Zhao B, Zhu Y, Chen Y, Duan Y, Han J*, Yang X*. LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells. Pharmacological Research 2019 Jun;144:167-180.

22.Han J*, Tan H, Duan Y, Chen Y, Zhu Y, Zhao B, Wang Y, Yang X*. The cardioprotective properties and the involved mechanisms of NaoXinTong Capsule. Pharmacological Research 2019. 141: 409-417.

23.Ma J, Zhao D, Wang X, Ma C, Feng K, Zhang S, Chen Y, Zhu Y, Gao X, Zhao B, Wang Y, Qian K, Li X, Duan Y, Han J*, Yang X*. LongShengZhi capsule reduces established atherosclerotic lesions in apoE deficient mice by ameliorating hepatic lipid metabolism and inhibiting inflammation. Journal of Cardiovascular Pharmacology 2019 Feb;73(2):105-117.

24.Liu Y#, Wei Z#, Zhang Y, Ma X, Chen Y, Yu M, Ma C, Li X, Cao Y, Liu J, Han J, Yang X*, Duan Y*. Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol. Journal of Lipid Research, 2018 Dec;59(12):2287-2296.

25.Li Q, Chen Y, Zhao D, Wei Z, Zhang S, Chen Y, Wang Y, Qian K, Zhao B, Zhu Y, Gao X, Li X, Duan Y, Han J*, Yang X*. NaoXinTong capsule inhibits carrageenan-induced thrombosis in mice. Journal of Cardiovascular Pharmacology, 2018, 72 (1) 49-59.

26.Yang S, Liu M, Chen Y, Ma C, Liu L, Zhao B, Wang Y, Li X, Zhu Y, Gao X, Kong D, Duan Y, Han J*, Yang X*. NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice. Scientific reports, 2018 Jun 14;8(1):9158. doi: 10.1038/s41598-018-26746-1.

27.Zhang W#, Yang X#, Chen Y#, Hu W, Liu L, Zhang X, Liu M, Sun L, Liu Y, Yu M, Li X, Li L, Zhu Y, Miao Q, Han J, Duan Y. Activation of hepatic Nogo-B receptor expression—A new anti-liver steatosis mechanism of statins. BBA - Molecular and Cell Biology of Lipid, 2018 Feb;1863(2):177-190.

28.Sun L#, Yang X#, Li Q, Liu Y, Chen Y, Liu L, Yu M, Ma C, Li X, Li Y, Zeng P, Han J, Duan Y. Activation of adiponectin receptor induces proprotein convertase subtilisin/kexin type 9 expression but ameliorates lipid metabolism in mice. Arteriosclerosis Thrombosis and Vascular Biology, 2017 Jul;37(7):1290-1300.

29.Yu M, Liu Y, Duan Y, Chen Y, Han J, Sun L*, Yang X*. Inhibition of glutathione production by L-S,R-buthionine sulfoximine activates hepatic ascorbate synthesis - A unique anti-oxidative stress mechanism in mice. Biochemical and Biophysical Research Communications. 2017 Feb 26;484(1):56-63.

30.Yang X#, Li Y#, Sun L, Liu Y, Ma C, Chen Y, Tan H, Li Q, Li X, Wang Y, Duan Y, Zhao B, Han J. NaoXinTong enhances atorvastatin-induced plaque stability while ameliorating atorvastatin-induced hepatic inflammation. Journal of Cardiovascular Pharmacology. 2017 Jan;69(1):55-64.

31.Yang X#, Zhang W#, Chen Y#, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J, Yajun Duan. Activation of PPARg and CD36 expression--the dual pathophysiological role of progesterone. Journal of Biological Chemistry, 2016;291:15108-18.

32.Yang X#, Sun L#, Li Y, Ma C, Yang J, Zhang W, Zhao B, Jia L, Duan Y, Han J, Li X, Chen Y. NaoXinTong inhibits the advanced atherosclerosis and enhances the plaque stability in apoE deficient mice. Journal of Cardiovascular Pharmacology, 2016;67 (3):203-11.

33.Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J, Duan Y. Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake. Journal of Biological Chemistry, 2015;290:21788-99.

34.杨潇潇，刘力沛，孙蕾，李小菊，段亚君，陈元利. 过氧化物酶体增殖物激活受体gamma激动剂和促分裂原活化蛋白激酶1/2抑制剂药物组合对Apoe-/-小鼠动脉粥样硬化发展的抑制作用. 中国动脉硬化杂志. 2015;23:763-768.

35.蒋晓萌，杨代刚，高永耀，邹庭峰，施存元，江宏，段亚君，杨潇潇*. 愈风宁心滴丸预防性治疗血管痉挛性偏头痛的作用及机制研究. 中草药. 2021,52(22)

2018年12月，中华医学会医学科学技术奖三等奖（排名第四）
2018年1月，2017年教育部高等学校科学研究优秀成果自然科学二等奖（排名第五）
2017年，南开大学研究生优秀毕业生
2016年，南开大学周恩来奖学金
2016年，博士研究生国家奖学金
2015年，博士研究生国家奖学金
2016年9月，《第十三届全国脂质与脂蛋白学术会议》“阳普杯”青年论文大赛二等奖
2014年10月，《第十二届全国脂质与脂蛋白学术会议》“阳普杯”青年论文大赛二等奖